The story is told from the perspectives of Chris Redfield, a former member and founder of the BSAA traumatized by a failed operation, Leon S. Kennedy, a Raccoon City survivor and agent for the U.S. government, Jake Muller, illegitimate son of Albert Wesker and associate of Sherry Birkin, and Ada Wong, a freelance agent framed for the bio-terrorist attacks by Neo-Umbrella. They must all confront the force behind a massive bio-terrorist attack with the newly developed C-virus in cities across the world.
Concept development began in 2009, with full development beginning the following year under Hiroyuki Kobayashi, who produced Resident Evil 4, and eventually grew to have the largest staff so far to work on a Resident Evil game. The game faced both negative reactions to the control problems with the demo and mixed reviews for the drastic shift in gameplay focus for the main game, being a point of both praise and criticism for different review outlets.